Welcome to the group of Wolfgang P. Meier !
Polymer supramolecular structures in the form of micelles, vesicles, and films are of particular interest as building blocks/templates for molecular factories. If appropriately designed from the point of view of chemical nature and properties, these structures can favour the insertion/encapsulation/attachment of biological molecules that serve as active blocks without dramatically impairing their function. Polymer vesicles and planar membranes selectively permit encapsulation or insertion of a variety of biomolecules, ranging from low molar mass components to functional enzymes and proteins, without hampering their activities. In addition, polymer membranes modified by the insertion of channel proteins allow for the selective exchange of molecular components/reaction products across the membrane, while the functionalization of their surfaces supports targeted approaches. Initially, the variety of amphiphilic copolymers, and later the multifunctionality and responsiveness of biomolecule – polymer assemblies will be extended, by integrating them in complex networks that will support molecular factories.
Decorating Nanostructured Surfaces with Antimicrobial Peptides to Efficiently Fight Bacteria
Rigo, S., Hürlimann, D., Marot, L., Malmsten, M., Meier, W. P., & Palivan, C. G.
ACS Applied Bio Materials, 2020
Synthesis and complex self-assembly of amphiphilic block copolymers with a branched hydrophobic poly(2-oxazoline) into multicompartment micelles, pseudo-vesicles and yolk/shell nanoparticles
Daubian, D., Gaitzsch, J., & Meier, W.
Polymer Chemistry, 2020
How Do the Properties of Amphiphilic Polymer Membranes Influence the Functional Insertion of Peptide Pores?
Belluati, A., Mikhalevich, V., Yorulmaz Avsar, S., Daubian, D., Craciun, I., Chami, M., ... & Palivan, C. G.
Molecular factories: The combination between nature and chemistry is functional
/ Research, People
Martina's and Tomaž's article is published in Advanced Science
/ Research, People
Andrea's and Viktoria's article is published in Biomacromolecules
Chemists Create Clusters of Organelles by Mimicking Nature
Wie sich natürliche Kanalproteine in künstlichen Membranen bewegen